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Fostering Groundbreaking Studies

The Institute for Surgical Advancement has harnessed the imagination of some of the most preeminent physicians in their fields to carry out basic, clinical and translational research. The ISA fosters groundbreaking studies by providing support and resources to promote the compliant and efficient conduct of research. A representative sampling of presented abstracts and published articles are listed here. For a more exhaustive list, please visit: www.ncbi.nlm.nih.gov/pubmed


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Research Studies

By utilizing the minds of some of the most preeminent physicians in their field, The Institute for Surgical Advancement fosters groundbreaking research studies by providing support and resources to promote the compliant and efficient conduct of research.


These brief point-of-entry works (summaries) of the research include the research focus, methods and findings along with conclusions and recommendations have been presented at national and international conferences by the ISA’s preeminent researchers.


These full-length manuscripts have been reviewed by a series of the researcher’s peers and has been deemed to suitable for review based upon it’s scientific merit.

A Sample of Our Work

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Regionalization Of Pancreatic Cancer Treatment Within The State Of Florida Hospital

Variability of outcomes of patients with pancreatic cancer at either low- versus high- volume institutions in the state of Florida are investigated in this study.
Scott Zenoni, Paula Veldhuis, W Steve Eubanks, J Pablo Arnoletti, Sebastian de la Fuente

Evaluating Epigenetic Gene Regulation In Circulating Tumor Cells Over Time and During Treatment

SA Litherland, PhD, E Griffith, CCRC, AJO Almodovar, MS, T Encarnacion, CRC, JP Arnoletti, MD, R Reynolds, MD, Y Khaled, MD, CC Chang, MD/PhD, S de la Fuente, MD, S Blaydes-Ingersoll, PhD, J Gaitan, MD, DA Decker, MD, T Mekhail, MD, X Zhu, MS, S Dickstein, P. Veldhuis, Y-P Shao, MBA, and R Sause, CHT

Pelvic Sentinel Lymph Node Status And Risk Of Aortic Nodal Metastasis In Patients With Endometrial Cancer

R.W. Holloway, J.A. James, C.N. Jeppson, A. Gubbi, E. Takimoto, N.M. Stavitzski, S. Ahmad

Presentation Patterns At A Dedicated HPB Tumor Board In A Tertiary Referral Center

Yaphet Tilahun, WS Eubanks MD, A Zakari, JP Arnoletti, de la Fuente SG

Overview Of A Chemoresponse Assay In Ovarian Cancer

E. C. Grendys Jr., J. V. Fiorica, J. W. Orr Jr., R. Holloway, D. Wang, C. Tian, J. K. Chan, T. J. Herzog

Robotic Transperitoneal Infra-Renal Aortic Lymphadenectomy In Early-Stage Endometrial Cancer

Jeffrey A. James, Joseph A. Rakowski, Corinne N. Jeppson, Nicole M. Stavitzski, Sarfraz Ahmad, Robert W. Holloway

Racial Disparities In Patients With Gallbladder Cancer

Scott Zenoni, Xiang Zhu, Paula Veldhuis, WS Eubanks MD, JP Arnoletti MD, de la Fuente SG

Prospective Validation Of Robotic Surgery Simulator For General Surgeons

Martin-Perez B, Veldhuis P, Arnoletti JP, Eubanks WS, de la Fuente SG

Enhancing Efficacy Of Cisplatin

Relevance of Sp1 and survivin expression in epithelial ovarian cancer patients and their usefulness as potential therapeutic targets
Umesh T. Sankpal1, Susan B. Ingersoll2, Vadiraja B. Bhat3, Sarfraz Ahmad2, Robert W. Holloway2, Riyaz M. Basha1. (1) UNT Health Science Center, Fort Worth, TX; (2) Florida Hospital Cancer Institute, Orlando, FL; (3) Agilent Technologies Inc, Wilmington, DE

Cytokine-Induced Killer Cells From Ovarian Cancer Patients Expanded Ex Vivo In The Presence Of IL-7 Improve Survival In A Xenograft Mouse Model Of Ovarian Cancer

Susan Blaydes Ingersoll, Ph.D.1, Milan Srivastava, M.S.1, Ghazanfar Ali, M.D.1, Zainab Mohiuddin, B.S.1, Erin R. Boone, B.S.1, Sarfraz Ahmad, PhD1, Robert K. Banks, B.S.2, Neil J. Finkler, MD1, John R. Edwards, M.D.3 and Robert W. Holloway, MD1, (1) Florida Hospital Cancer Institute, Orlando, FL, (2) University of Central Florida, Orlando, FL, (3) Indiana Blood and Marrow Transplantation, Indianapolis, IN


Pancreatic Adenocarcinoma: A Pilot Study Of Quantitative Perfusion And Diffusion-Weighted Breath-Hold Magnetic Resonance Imaging

Kim H, Arnoletti PJ, Christein J, Heslin MJ, Posey JA 3rd, Pednekar A, Mark Beasley T, Morgan DE Abdom Imaging. 2014 Aug;39(4):744-52. doi: 10.1007/s00261-014-0107-z. 
Link to Publication

In Vivo Diagnosis Of Clonorchiasis During Cholangioscopy For Workup Of Suspected Cholangiocarcinoma (With Video)

Tang RS, Reddy DN, Teoh AY, Lam KL, Hawes RH. Gastrointest Endosc. 2014 Apr 12. pii: S0016-5107(14)01197-3. doi: 10.1016/j.gie.2014.02.1027. 
Link to Publication

International Multicenter Experience With An Over-The-Scope Clipping Device For Endoscopic Management Of GI Defects (With Video)

Haito-Chavez Y, Law JK, Kratt T, Arezzo A, Verra M, Morino M, Sharaiha RZ, Poley JW, Kahaleh M, Thompson CC, Ryan MB, Choksi N, Elmunzer BJ, Gosain S, Goldberg EM, Modayil RJ, Stavropoulos SN, Schembre DB, DiMaio CJ, Chandrasekhara V, Hasan MK, Varadarajulu SHawes R, Gomez V, Woodward TA, Rubel-Cohen S, Fluxa F, Vleggaar FP, Akshintala VS, Raju GS, Khashab MA. Gastrointest Endosc. 2014 Jun 4. 
Link to Publication

Prevalence Of Normal Liver Tests In Patients With Choledocholithiasis Undergoing Endoscopic Retrograde Cholangiopancreatography.

Wilcox CM, Kim H, Trevino J, Ramesh J, Monkemuller K, Varadarajulu S. Digestion. 2014;89(3):232-8. 2014 Jun 4. 
Link to Publication

The 25-Gauge EUS-FNA Needle: Good For On-Site But Poor For Off-Site Evaluation? Results Of A Randomized Trial

Varadarajulu S, Bang JY, Holt BA, Hasan MK, Logue A, Hawes RH, Hebert-Magee S. Gastrointest Endosc. 2014 Jun 25. 
Link to Publication 

High-Quality Endoscopic Ultrasound-Guided Fine Needle Aspiration Tissue Acquisition

Holt BA, Varadarajulu S, Hébert-Magee S. Adv Ther. 2014 Jun 24. 
Link to Publication

Relationship Between Stent Characteristics And Treatment Outcomes In Endoscopic Transmural Drainage Of Uncomplicated Pancreatic Pseudocysts.

Bang JY, Mel Wilcox C, Trevino JM, Ramesh J, Hasan M, Hawes RHVaradarajulu S. Surg Endosc. 2014 May 2. 
Link to Publication

Prophylactic Arrhythmia Surgery In Association With Congenital Heart Operations: A Critical Review And Recommendations

Mavroudis C, Stulak JM, Ad N, Siegel A, Giamberti A, Harris L, Backer CL, Tsao S, Dearani J, Weerasena N, Deal BJ.
Link to Publication

Outcomes After Implementing A Tailored Endoscopic Step-Up Approach To Wall-Off Necrosis In Acute Pancreatitis

Bang JY, Holt BA, Hawes RH, Hasan MK, Arnoletti JP, Christein JD, Wilcox CM, Varadarajulu S Br J Surg. 2014 Dec;101(13):1729-38. doi: 10.1002/bjs.9664. 
Link to Publication

Beyond Cytology: Why And When Does The Oncologist Require Core Tissue?

de la Fuente SGArnoletti JP. Gastrointest Endosc Clin N Am. 2014 Jan;24(1):9-17. doi: 10.1016/j.giec.2013.08.001. 
Link to Publication

Vagotomy/Drainage Is Superior To Local Oversew In Patients Who Require Emergency Surgery For Bleeding Peptic Ulcers.

Schroder VT, Pappas TN, Vaslef SN, de la Fuente, SG, Scarborough JE. Ann Surg. 2014 Jun;259(6):1111-8. doi: 10.1097/SLA.0000000000000386. 
Link to Publication

Indications For Fontan’s Operation In Patients With Cono-Truncal Anomalies. In, Surgery Of Cono-Truncal Anomalies

Mavroudis C, Mavroudis CD, Siegel A Lacour-Gayet F, Bove E, Hraska V, Morell V, and Spray T, eds. Springer, 2014.

Tricuspid Valve Repair In Non-Ebstein’s Patients

Ali-Dodge A, Frost JL, Mavroudis C: Tricuspid Valve Repair in non-Ebstein’s Patients. Giamberti A et al, Eds. The Tricuspid Valve. Springer, 2014; 24: 1077-1087. 
Link to Publication

Ethical Issues Confronting Outcomes Analysis And Quality Assurance. Pediatric And Congenital Cardiac Disease

Mavroudis CD, Jacobs JP, Siegel A, Mavroudis C: Ethical issues confronting outcomes analysis and quality assurance. Pediatric and Congenital Cardiac Disease (Barach, Jacobs, Laussen, Lipshultz, eds. Springer, 2014. 
Link to Publication