Search our team at AdventHealth Research Institute
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Prospective Registry for Colorectal Cancer: International Watch and Wait Database
This study is not currently enrolling.Associated Conditions: Colorectal CancerResearch Area: Clinical Cancer ResearchThis research is being done as part of a larger international database for 'Watch and Wait' rectal cancer patients. Currently, the 'Watch and Wait' treatment shows promising results worldwide, however...
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NCT03519945
A Phase 3, Multicenter, Open-Label Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis
This study is not currently enrolling.Associated Conditions: ColonResearch Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaThis study is being done to help answer the following research questions: (a) How mirikizumab, an investigational drug, could help people with ulcerative colitis over time; (b) How safe long-term use...
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NCT04284774
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 subprotocol of Tipifarnib in Patients with Tumors Harboring HRAS Genomic Alterations
This study is not currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis is a Phase 2 study of a study drug called tipifarnib. The main goal of the study is to find out what effect, good and/or bad effects the study drug tipifarnib may have on your tumor. A second...
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NCT04195555
APEC1621K NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) - Phase 2 Subprotocol of AG-120 (Ivosidenib) in Patients with Tumors Harboring IDH1 Mutations.
This study is not currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe main goal is to find out what effect, good and/or bad effects AG-120 (ivosidenib) on your tumor. A second goal of the study is to evaluate side effects that might be caused by AG-120 (ivosidenib)...
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NCT04285658
Pediatric KIDney Stone (PKIDS) Care Improvement Network
This study is not currently enrolling.Associated Conditions: SurgeryResearch Area: Pediatric Research and Clinical TrialsThe purpose of this study is to improve the ability of pediatric patients and their caregivers to select surgical treatment options for kidney stones. The study also aims to help urologists use...
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PIONEER 4: A Study Investigating the Efficacy and Safety of Oral Semaglutide versus Liraglutide and versus Placebo in Subjects with Type 2 Diabetes Mellitus
This study is not currently enrolling.Research Area: Translational ResearchBefore a new medicine can be approved for use in humans, it is necessary to confirm that it is safe and effective. This is done by carrying out studies such as this one. The study product semaglutide...
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NCT01843127
GILEAD: A Phase 1, Randomized, Single-blind, Placebo-controlled, Multiple-dose, Two-sequence, Cross-over Study to Evaluate the Effect of Ranolazine on Glucagon Secretion in Subjects with Type 2 Diabetes Mellitus, Followed by An Open-label, Single-dose, Exenatide Active-control Period
This study is not currently enrolling.Research Area: Translational ResearchThe primary purpose of this study is to understand the reasons why Ranolazine may potentially treat patients with T2DM. Ranolazine has been shown to block glucagon and therefore results in a lowering...
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NCT03919071
A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND# 145355)
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Clinical Cancer ResearchThe study doctors want to see if using dabrafenib and trametinib after radiation treatment will be better than treatments used in the past in helping to get rid of or shrink HGGs. Dabrafenib works by...
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NCT02723994
A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib with Chemotherapy in Children with De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Pediatric Research and Clinical TrialsThe overall goal of this study are to: Part 1 - Find the best dose of ruxolitinib to use with standard chemotherapy in children, adolescents, and young adults with HR B-ALL; Part 2 - Find out if the...
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VTEM PLASMA MARKERS - Plasma Biomarkers for Veno-ThromboEmbolic (VTE) Disease: Promise of Metabolomics (VTEM)
This study is not currently enrolling.Associated Conditions: Veno-Thromboembolic DiseaseResearch Area: Heart, Lung and Vascular ResearchWe invite you to take part in a research study because you have been diagnosed of having a blood clot in your body either in the legs called DVT deep vein thrombosis or possibly in your lungs called...
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Routine versus No Assessment of Gastric Residual Volumes in Very Low Birth Weight Infants Receiving Enteral Feeding via Intermittent Feeding Tubes: A Randomized Controlled Trial
This study is not currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaPre term infants require feeding tubes when they start receiving feeds. Once the volume of milk increases, the current practice in our Neonatal Intensive Care Unit (NICU) is to attach a syringe to the...
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Validation of the Pediatric Critical-care Pain Observation Tool (P-COPT) in PICU and Pediatric CVICU
This study is not currently enrolling.Research Area: Pediatric Research and Clinical TrialsThe specific aim of the proposed study is to further validate the P-CPOT in PICU and Pediatric CVICU ventilated patients who are 3 to 18 years.