Search our team at AdventHealth Research Institute
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NCT05394519
REDEFINE2: Efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) once-weekly in participants with overweight or obesity and type 2 diabetes.
This study is not currently enrolling.Associated Conditions: Diabetes-Drug StudyResearch Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of the study is to investigate the efficacy and safety of two medications, cagrilintide and semaglutide. Cagrilintide in combination with semaglutide is currently under...
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NCT05364073
FURMO-002: A Phase 1b Dose Escalation and Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Antitumor Activity of Furmonertinib in Patients with Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) with Activating EGFR or HER2 Mutations, Including Exon 20 Insertion Mutations
This study is not currently enrolling.Associated Conditions: Lung CancerResearch Area: Clinical Cancer ResearchThe purpose of this study is to learn about how the study drug, furmonertinib, works in patients with NSCLC who have a mutation in the EGFR or HER2 gene and how it may help them. For patients with...
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NCT04223752
A Phase 1, open-label, non-comparative, multicenter clinical study to evaluate the safety, tolerability, and pharmacokinetics of ceftolozane/tazobactam (MK-7625A) in pediatric participants with nosocomial pneumonia
This study is not currently enrolling.Research Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaCeftolozane/tazobactam, also known as Zerbaxa, is a combination product, and is available by prescription for use in adults for the treatment of complicated urinary tract infections, including...
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NCT04529772
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R CHOP) in Subjects ≤70 Years with Previously Untreated Non-Germinal Center Diffuse Large B Cell Lymphoma
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis study is being done to understand whether patients with a type of DLBCL known as non-germinal center diffuse large B-cell lymphoma (non-GCB DLBCL) will benefit from the addition of acalabrutinib...
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Donor Breast Milk and Serum Ferritin Levels in Very Preterm Infants: A Prospective, Observational Study
This study is not currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThe purpose of the study is to compare the iron levels in very preterm infants receiving donor breast milk (DBM) to very preterm infants receiving maternal breast milks (MBM).
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NCT03000439
You are being asked to take part in this research study because you have Systemic Juvenile Idiopathic Arthritis (sJIA) which may cause joint swelling and pain, fever, or other symptoms affecting the whole body (such as rash, swelling of your lymph nodes, a large liver or spleen, or inflammation of the lining around your lungs or heart). The purpose of this research study is to compare the effectiveness of the study drug, tofacitinib, to placebo for treatment of signs and symptoms of sJIA.
This study is not currently enrolling.Associated Conditions: Immunology/RheumatologistResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaYou are being asked to take part in this research study because you have Systemic Juvenile Idiopathic Arthritis (sJIA) which may cause joint swelling and pain, fever, or other symptoms affecting the...
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Edited Natural Killer cells as an immunotherapeutic approach for the treatment of pediatric cancers
This study is not currently enrolling.Associated Conditions: Pediatric CancerResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaFreshly resected tumor tissue obtained from neuroblastoma patients will be used to establish in vitro organoid models and characterize the tumor landscape before and after in vitro allogeneic edited...
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NCT05232929
LONG-TERM FOLLOW-UP STUDY OF PATIENTS WITH SPINAL MUSCULAR ATROPHY RECEIVING RISDIPLAM TREATMENT
This study is not currently enrolling.Associated Conditions: NeurodegenerativeResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe main purpose of this study is to follow patients receiving Evrysdi for a long time. This will add to the body of evidence about the safety and effectiveness of Evrysdi.
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NCT04471909
TRIOMPHE - A Multi-arm, Multi-Center, Non-Randomized, Prospective, Clinical Study to Evaluate the Safety and Effectiveness of the NEXUS Aortic Arch Stent Graft System in Treating Thoracic Aortic Lesions Involving the Aortic Arch
This study is not currently enrolling.Research Area: Transplant ResearchResearch Location: Orlando, FloridaThis study involves research. The purpose of this research study is to continue to test how well the Endospan NEXUS Aortic Arch Stent Graft System performs in the treatment of a diseased aortic arch...
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NCT03683186
ADVANCE EXTENSION - A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects with PAH via an Open-Label Extension
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchIf you have taken part in a research study with ralinepag, the investigational study drug, you may be able to take part in this extension study. This means that all participants will receive the...
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Randomized Trial on Hybrid vs Non-Hybrid ESD for Colorectal Polyps
This study is not currently enrolling.Research Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaWe invite you to take part in a research study because you have colorectal polyp and are being treated here at AdventHealth Orlando. A clinical trial (research study) is done when researchers...
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NCT05194072
A Phase 1 Study of SGN-B7H4V in Advanced Solid Tumors
This study is not currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Clinical Cancer Research