Foot blisters are extremely common, and most people will experience many of these during the course of their lifetime. They commonly occur at sites of friction, typically from ill-fitting shoes and socks that retain moisture or fall and bunch. If possible, keep the blister intact and avoid popping the fluid-filled bubble. If a blister is especially uncomfortable, particularly large or continues to be irritated, carefully popping it using a sterile needle may help alleviate pressure and pain. Whether popped with a needle or on accident, the new skin developing under the blister needs the skin over the broken blister and typically a bandage for protection while it heals. Blisters that seep white or yellow fluid are infected and should be assessed by a doctor. Diabetics who incur blisters on the feet should see a physician to proactively prevent infection.