Translational Research Clinical Trials
Search our team at AdventHealth Research Institute
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NCT06745284
An active-comparator-controlled, open-label, parallel group study to evaluate the effect of survodutide on energy expenditure and fatty acid oxidation in subjects with obesity
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaA study to test whether survodutide improves how the body uses energy and breaks down fat in people with obesity.
To be enrolled in this study, you must meet certain requirements. You may be eligible...
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NCT06993454
ACELERATE-P: Acute exercise and endogenous glucose production in type 2 diabetes: Implications for glycemic control and treatment of hepatic steatosis
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaThe overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by your liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis...
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NCT06602141
ATLAS: Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise
This study is currently enrolling.Associated Conditions: ExerciseResearch Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin resistance in people with obesity.
To be enrolled...
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NCT06484114
REMAIN-1: A Prospective, Randomized, Double-Blind, Sham-Controlled, Multicenter, Pivotal Study to Assess the Efficacy of Revita Duodenal Mucosal Resurfacing (DMR) on Body Weight Maintenance in Participants with Obesity and Who Have Achieved at Least 15% Weight Loss on Tirzepatide Obesity Pharmacotherapy
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaREMAIN-1 The purpose of this research is to see if doing a procedure that temporarily removes the lining of your duodenum (first part of your small intestine) can help you keep from regaining weight...
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NCT05984238
RECET: A Multicenter, Double-blind, Sham-controlled Study for Assessing the Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals with Type 2 Diabetes
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: To study changes in blood glucose control and weight loss in Type II Diabetics using Nutrition and Lifestyle Counseling combined with an investigational device called the ReCET...
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ENABLE: Clinical validation of islet autoantibody measurement in self-collected dried blood spot specimens
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: Clinical validation of islet autoantibody measurement in self-collected dried blood spot specimens.
To be enrolled in this study, you must meet certain requirements. You may be...
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FABULINUS: A 52-week randomized, double-blind, placebo controlled, multi-center Phase 2b study with a 52-week blinded extension assessing safety and efficacy of frexalimab, a CD40L-antagonist monoclonal antibody, for preservation of pancreatic beta-cell function in adults and adolescents with newly diagnosed type 1 diabetes on insulin therapy.
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The study is aimed to evaluate an investigational drug, frexalimab, for preservation of pancreatic beta cell function in adults and adolescents that have been newly diagnosed with Type...
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NCT06008977
EX-BOOST: Exercise to boost response to checkpoint blockade immunotherapy
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: To obtain a better understanding on how exercise can improve outcomes for patients with skin cancers.
To be enrolled in this study, you must meet certain requirements. You may be...
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COMET: ImpaCt Of shiftwork on METabolic Flexibility and Skeletal Muscle Clocks.
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: To determine how working a nighttime shift impacts your metabolism.
To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you meet the...
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NCT05197920
DREAM: Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM). An observational cohort study from the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)
This study is currently enrolling.Associated Conditions: Diabetes-Drug StudyResearch Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this research study is to find out how many people with acute pancreatitis develop diabetes. Risk factors for diabetes and the types of diabetes that occur after acute...
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NCT04807868
AVAIL: AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry
This study is currently enrolling.Associated Conditions: Liver-NAFL, NASHResearch Area: Translational ResearchResearch Location: Orlando, FloridaNon-alcoholic fatty liver disease (NAFLD) is a common liver disease that leads to many health complications. Many people have this disease and do not know it. There are no medications available to...
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NCT00097292
TRIALNET: Natural History Study of the Development of Type 1 Diabetes
This study is currently enrolling.Associated Conditions: Diabetes-MechanismsResearch Area: Translational ResearchResearch Location: Orlando, FloridaYou are being asked to be in a research study called the TrialNet Natural History Study of the Development of Type 1 Diabetes. As you know, TrialNet is an international research group dedicated to the...