ACELERATE-P: Acute exercise and endogenous glucose production in type 2 diabetes: Implications for glycemic control and treatment of hepatic steatosis. The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by your liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).

Study Purpose: To investigate the effects of exercise on the amount of glucose that is made by your liver in people with Type 2 diabetes (T2D) and fatty liver and those without.
Study Duration: 4 weeks
Study Commitment: • 2 Screening Visits (ICF, blood work, ECG, waist and hip measurement, physical exam,) and questions about your medical history)
• 4 outpatient visits
• 2 Overnight visits
• 1 phone call visit
Age: 25-65
Sex: Male & Female
Conditions/Eligibility: T2D
-Body mass index (BMI) between 25 and 55kg/m2
-Sedentary (1 day or less per week of structured exercise)
-Type 2 diabetes mellitus: HbA1c ≥6.5%
-Weight stable (± 2 kg) for prior 3 months
Study Procedures: • Physical exam, vital signs, height, weight, BMI, screening labs, urine screen, measurement of waist and hip circumference, EKG
• DEXA
• FibroScan
• Multiple Questionnaires
• Medical and medication history
• VO2 Max (fitness test)
• CGM Placement and training
• Labeled Glucose IV Infusion
• Labeled oral glucose challenge
• Exercise challenge
• Multiple blood draws
• MRI (Magnetic resonance imaging)
Compensation: $600