ACELERATE-P: Acute exercise and endogenous glucose production in type 2 diabetes: Implications for glycemic control and treatment of hepatic steatosis. The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by your liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).

The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by your liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).
4 weeks
2 Screening Visits (ICF, blood work, ECG, waist and hip measurement, physical exam,) and questions about your medical history)
4 outpatient visits
2 Overnight visits
*2 Phone-Call Follow-ups
25-65 years old
Male & Female
- Liver fat ≥5.6% based on MRI
- Weight stable (± 2 kg) for prior 3 months
Physical exam, vital signs, height, weight, BMI, screening labs, urine screen, measurement of waist and hip circumference, EKG
• DEXA
• FibroScan
• Multiple Questionnaires
• Medical and medication history
• VO2 Max
• CGM Placement and training
• Labeled Glucose IV Infusion
• Labeled Oral glucose challenge
• Exercise challenge
• Multiple blood draws
• MRI
$600