Search our team at AdventHealth Research Institute
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NCT05637801
A Randomized, Double-blind, Sham-controlled, Adaptive- Design Pivotal Study of Sensory Stimulation in Subjects with Alzheimer’s Disease
This study is currently enrolling.Associated Conditions: NeurodegenerativeResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaIn this study, researchers want to find out if sensory stimulation delivered using the Sensory Stimulation System may help slow disease progression in people with mild to moderate Alzheimer’s disease...
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NCT05463731
A Study of Remternetug Versus Placebo in Early Alzheimer’s Disease Participants at Risk for Cognitive and Functional Decline
This study is currently enrolling.Research Area: Neuroscience ResearchResearch Location: Orlando, FloridaThis study is looking to assess the effect of remternetug versus
placebo on time to clinically meaningful
progression in participants with early AD. -
NCT06578247
A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial of Quizartinib Administered in Combination with Induction and Consolidation Chemotherapy and Administered as Maintenance Therapy in Adult Patients with Newly Diagnosed FLT3-ITD Negative Acute Myeloid Leukemia (QuANTUM-Wild)
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to learn more about an investigational drug called QUIZARTINIB. An investigational drug is a drug that is being studied to see if is safe, and to see if your disease or...
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NCT06525220
MCLA-158-CL03: A phase III randomized, open label study to evaluate the efficacy and safety of Petosemtamab plus Pembrolizumab vs. Pembrolizumab in head and neck squamous cell carcinoma in the first line treatment of PD-L1+ (CPS?1) metastatic/recurrent disease without curative therapy available
This study is currently enrolling.Associated Conditions: Head and Neck CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purposes of this Study are to find out the possible side effects of the Study Drug, when used in combination with another, already approved, drug named pembrolizumab; if the Study Drug can or...
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NCT06414603
23-069-TRP: A Comparative Effectiveness Study in Heart Transplant Patients of Rejection Surveillance With Cell-free DNA Versus Endomyocardial Biopsy (ACES-EMB)
This study is currently enrolling.Associated Conditions: Heart Transplant RejectionResearch Area: Transplant ResearchResearch Location: Orlando, FloridaA Comparative Effectiveness Study in Heart Transplant Patients of Rejection Surveillance with Cell-free DNA versus Endomyocardial Biopsy
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NCT06602141
Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise
This study is currently enrolling.Associated Conditions: ExerciseResearch Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin resistance in people with obesity.
To be enrolled...
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NCT05761171
AALL2121: A Phase 2 Study of SNDX-5613 in Combination with Chemotherapy for Patients with Relapsed or Refractory KMT2A-Rearranged Infant Leukemia
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe overall goal of this study is to determine the safety and best dose of the drug SNDX-5613 for young children when given in combination with chemotherapy, and to see if this treatment will improve...
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NCT0645646
A Phase II multicenter open-label trial of tagraxofusp (Tag) in combination with venetoclax and azacitidine (Ven/Aza) in adults with previously untreated CD123+ acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy.
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaOverall, the goal of this research study is to determine if tagraxofusp (Tag) in combination with venetoclax (Ven) and azacitidine (Aza) can safely treat cancer in patients who have not received...
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K23 APATHY: Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
This study is currently enrolling.Research Area: Neuroscience ResearchResearch Location: Orlando, FloridaStudy Purpose: This study is exploring a new treatment to help improve depression in older adulthood. The study will look at the effects of a digital cognitive intervention on mood and brain health in...
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NCT06579105
SOLSTICE: A Phase IIb, Randomized, Double-blind, Placebo-controlled and Open-label Active Comparator Study to Evaluate the Efficacy, Safety, and Tolerability of AZD5004 in Adults with Type 2 Diabetes Mellitus
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this study is to evaluate if the study medication AZD5004 can help improve glycemic control in persons with type 2 diabetes in conjunction with diet and exercise as...
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NCT06203600
Randomized Phase II/III Trial of 2nd Line Nivolumab + Paclitaxel + Ramucirumab versus Paclitaxel + Ramucirumab in Patients with PD-L1 CPS ? 1 Advanced Gastric and Esophageal Adenocarcinoma (PARAMUNE)
This study is currently enrolling.Associated Conditions: Esophageal CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis study is being done to answer the following questions: Can adding a drug to the usual treatment for advanced stomach and esophageal cancers make it less likely that these cancers will grow or...
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NCT05932615
Evaluation of the Navitor Transcatheter Heart Valve in Low and Intermediate Risk Patients who have Severe, Symptomatic, Aortic Stenosis Requiring Aortic Valve Replacement
This study is currently enrolling.Associated Conditions: Aortic StenosisResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaAortic stenosis is a type of heart valve disease where the valve located between the lower left heart chamber and the body’s main artery (aorta) becomes narrowed and cannot open completely. This...