All Clinical Trials
Search our team at AdventHealth Research Institute
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NCT05611931
A Phase 3, Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial of Selinexor in Maintenance Therapy After Systemic Therapy for Patients With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
This study is currently enrolling.Associated Conditions: Endometrial CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this Phase 3 study is to compare the PFS of patients receiving Selinexor maintenance therapy after prior systemic therapy to the PFS of patients receiving placebo as maintenance therapy...
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NCT06172296
A Phase 3 Study of Dinutuximab Added to Intensive Multimodal Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
This study is currently enrolling.Associated Conditions: NeuroblastomaResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaThe overall goals of this study are to
Compare the outcomes of dinutuximab given early with Induction therapy to the effects of standard Induction therapy with the addition of dinutuximab later in... -
NCT06619561
A Phase 2, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, PK, and Efficacy of Vimseltinib in Adults With Active Chronic GVHD After Failure of Prior Systemic Therapy
This study is currently enrolling.Research Area: Clinical Cancer ResearchResearch Location: Orlando, Florida -
NCT05812807
OptimICE-PCR: De-Escalation of Therapy in Early-Stage TNBC Patients Who Achieve pCR After Neoadjuvant Chemotherapy with Checkpoint Inhibitor Therapy
This study is currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchThis study is being done to answer the following question: Among patients with early-stage TNBC who achieve a pCR after preoperative chemotherapy in combination with pembrolizumab, will observation...
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NCT06993454
ACELERATE-P: Acute exercise and endogenous glucose production in type 2 diabetes: Implications for glycemic control and treatment of hepatic steatosis
This study is currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaThe overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by your liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis...
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NCT06760637
An Interventional, Open-label, Randomized, Multicenter Phase 3 Study of PF-07220060 plus Letrozole Compared to CDK4/6 Inhibitor Plus Letrozole in Participants over 18 Years with Hormone Receptor (HR)-Positive, HER2-Negatrive Advanced/Metastatic Breast Cancer Who Have Not Received Any Prior Systemic Anti-Cancer Treatment for Advanced/Metastatic Disease
This study is currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchResearch Location: Altamonte, FloridaThe purpose of the study is to evaluate whether PF-07220060 plus letrozole can improve clinical outcomes relative to cyclin-dependent kinase (CDK) 4/6 inhibitor (CDK4/6i) (investigator’s choice...
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NCT06492616
Elacestrant versus Standard Endocrine Therapy in Women and Men with Node-positive, Estrogen Receptor-positive, HER2-negative, Early Breast Cancer with High Risk of Recurrence - A Global, Multicenter, Randomized, Open-label Phase 3 Study (ELEGANT)
This study is currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchResearch Location: Altamonte, FloridaIn this study, we are testing a new endocrine therapy, called elacestrant, that is an endocrine therapy that stops hormones from attaching to cancer cells and helping them grow. Researchers would like...
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NCT06578247
A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial of Quizartinib Administered in Combination with Induction and Consolidation Chemotherapy and Administered as Maintenance Therapy in Adult Patients with Newly Diagnosed FLT3-ITD Negative Acute Myeloid Leukemia (QuANTUM-Wild)
This study is currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to learn more about an investigational drug called QUIZARTINIB. An investigational drug is a drug that is being studied to see if is safe, and to see if your disease or...
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NCT06525220
MCLA-158-CL03: A phase III randomized, open label study to evaluate the efficacy and safety of Petosemtamab plus Pembrolizumab vs. Pembrolizumab in head and neck squamous cell carcinoma in the first line treatment of PD-L1+ (CPS?1) metastatic/recurrent disease without curative therapy available
This study is currently enrolling.Associated Conditions: Head and Neck CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purposes of this Study are to find out the possible side effects of the Study Drug, when used in combination with another, already approved, drug named pembrolizumab; if the Study Drug can or...
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Specimen Collection for the Study of Solid Tumors and Other Diseases
This study is currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Shawnee Mission, KansasWe are collecting these samples to study diseases such as cancer, heart disease, musculoskeletal disease (bones and joints), blood disease (such as leukemia, lymphoma and multiple myeloma [cancer of...
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NCT06170268
Alzheimer’s Association / “Alzheimer’s Network for Treatment and Diagnostics (ALZ-NET)”.
This study is currently enrolling.Associated Conditions: NeurodegenerativeResearch Area: Neuroscience Research -
NCT06414603
23-069-TRP: A Comparative Effectiveness Study in Heart Transplant Patients of Rejection Surveillance With Cell-free DNA Versus Endomyocardial Biopsy (ACES-EMB)
This study is currently enrolling.Associated Conditions: Heart Transplant RejectionResearch Area: Transplant ResearchResearch Location: Orlando, FloridaA Comparative Effectiveness Study in Heart Transplant Patients of Rejection Surveillance with Cell-free DNA versus Endomyocardial Biopsy