Photo of Paul M. Coen, PhD

Paul M. Coen, PhD

Associate Investigator at the Translational Research Institute

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Expertise of Paul M. Coen, PhD

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Biography

Dr. Paul Coen is an Associate Investigator at the Translational Research Institute, AdventHealth Orlando.

Paul’s research program is supported by the National Institutes of Health (NIH) and is broadly focused on elucidating the role of skeletal muscle mitochondrial energetics in the pathophysiology’s associated with aging and obesity.
Paul’s postdoctoral training was in the area of muscle metabolism under the mentorship of Dr. Bret Goodpaster at the University of Pittsburgh’s Division of Endocrinology and Metabolism (2008-2010). His postdoctoral work resulted in authorship on numerous peer-reviewed publications in high impact journals such as the Journal of Clinical Investigation, Diabetes, and Diabetes Care.

Originally hailing from Dublin, Ireland, Paul made the jump across the pond to study for a PhD in Exercise Physiology at Purdue University, which he completed in 2008. Prior to this, he completed an M.S. in Vascular Biology at the Vascular Health Research Center (VHRC) at Dublin City University (2004), and received his initial didactic and laboratory-based training with a B.Sc. in Bioanalytical Science from the Institute of Technology, Tallaght, Ireland (2000).

Education

Purdue University, West Lafayette, IN

Fellowship

University of Pittsburgh School of Medicine

Publications of Paul M. Coen, PhD
  • Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers
    , FREE RADICAL BIOLOGY AND MEDICINE

  • Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA)
    , JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

  • Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis
    , ARTHRITIS & RHEUMATOLOGY

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  • Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA)
    , JOURNAL OF SPORT AND HEALTH SCIENCE

  • Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging
    , JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

  • The mitochondrial multi-omic response to exercise training across rat tissues
    , CELL METABOLISM

  • Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging
    , AGING CELL

  • Higher expression of denervation-responsive genes is negatively associated with muscle volume and performance traits in the study of muscle, mobility, and aging (SOMMA)
    , AGING CELL

  • Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women
    , OBESITY

  • Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA)
    , AGING CELL

Associated Clinical Trials for Paul M. Coen, PhD