Photo of Bret H. Goodpaster, PhD

Bret H. Goodpaster, PhD

Scientific Director at the Translational Research Institute

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Expertise of Bret H. Goodpaster, PhD

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Biography

Bret Goodpaster, Ph.D. investigates the pathophysiology of human aging, obesity, insulin resistance, and diabetes, and the biological mechanisms underlying the health benefits of exercise.

Dr. Goodpaster has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others? Which are the good fats and which are the bad fats?

Dr. Goodpaster has published >250 peer-reviewed papers, review articles and book chapters, has served on several Editorial Boards, and is currently an Associate Editor for Diabetologia. He has served on grant review panels for the NIH and the American Diabetes Association.

Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University. Prior to coming to the AdventHealth Translational Research Institute, he was Professor of Medicine and UPMC Chair for Diabetes and Metabolism Research at the University of Pittsburgh.

Education

Ball State University, Muncie, IN

Fellowship

University of Pittsburgh, Pittsburgh, PA; Maastricht University in the Netherlands,

Publications of Bret H. Goodpaster, PhD
  • Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers
    , FREE RADICAL BIOLOGY AND MEDICINE

  • Cardiopulmonary Exercise Testing in a Prospective Multicenter Cohort of Older Adults
    , MEDICINE & SCIENCE IN SPORTS & EXERCISE

  • Cardiopulmonary Exercise Testing in a Prospective Multicenter Cohort of Older Adults
    , MEDICINE & SCIENCE IN SPORTS & EXERCISE

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  • Role of Walking Energetics and Perceived Fatigability Differs by Gait Speed: The Study of Muscle, Mobility and Aging (SOMMA)
    , JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

  • Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis
    , ARTHRITIS & RHEUMATOLOGY

  • Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA)
    , JOURNAL OF SPORT AND HEALTH SCIENCE

  • Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging
    , JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

  • The mitochondrial multi-omic response to exercise training across rat tissues
    , CELL METABOLISM

  • Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women
    , OBESITY

  • Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
    , NATURE METABOLISM

Associated Clinical Trials for Bret H. Goodpaster, PhD