Cancer Research Clinical Trials
Search our team at AdventHealth Research Institute
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NCT06459869
A multicentre, open label, non-randomized, phase 1b trial of NG-350A, a tumourselective anti-CD40-expressing adenoviral vector, in combination with chemoradiotherapy in locally advanced rectal cancer (FORTRESS)
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this research is to test an investigational drug called NG-350A as a possible treatment for locally advanced rectal cancer (LARC). An investigational drug is one that has not been...
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NCT05773144
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this research study is to determine if different durations of exercise can improve how well you tolerate chemotherapy for colon cancer.
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NCT05789433
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Clinical Cancer ResearchResearch Location: OrlandoRESTORE-The purpose of this research study is to determine how different types of exercise change muscle tissue among people who have been diagnosed with colorectal cancer.
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NCT06745024
Radiation Therapy for High-Risk Asymptomatic Bone Metastases: A Pragmatic Multicenter Randomized Phase 3 Clinical Trial (PREEMPT)
This study is currently enrolling.Associated Conditions: RadiationResearch Area: Clinical Cancer ResearchResearch Location: Porter, Colorado -
NCT06767514
A Randomized, Double-blinded, Multiregional Phase 3 Study of Ivonescimab Versus Pembrolizumab for the First-line Treatment of Metastatic Non-small Cell Lung Cancer in Patients Whose Tumors Demonstrate High PD-L1 Expression (TPS greater than or equal to 50%)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this research is to measure the safety and effectiveness of ivonescimab compared to pembrolizumab. Ivonescimab is an antibody designed to block proteins that help cancer cells grow and...
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NCT07223125
A Phase 1 Study of JNJ-89862175, an Antibody Drug Conjugate (ADC) Agent Targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 (ENPP3), for Advanced Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationA Phase 1 Study of JNJ-89862175, an Antibody Drug Conjugate (ADC) Agent Targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 (ENPP3), for Advanced Solid Tumors
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NCT06452277
A Phase 3 open-label, randomized, active-controlled, multicenter trial to evaluate the efficacy and safety of orally administered BAY 2927088 compared with standard of care as a first-line therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with HER2-activating mutations (SOHO-02)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this study is to look at how well the new study drug works compared to standard medical care in participants with non-small cell lung cancer
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NCT06819007
A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer” GOG 3112/ DSI-T-DXd ENHERTU (DO-01); DESTINY-Ovarian01 (DO-01)] DS8201-772
This study is currently enrolling.Associated Conditions: GynecologyResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis study consists of two parts: Part 1 (safety run-in) and Part 2 (randomized part [like the flip of a coin]). The purpose of Part 1 is to learn more about the safety and tolerability of the...
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NCT06745323
A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects with Small Cell Lung Cancer (SCLC) (DeLLphi-309)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis study is being done to learn more about tarlatamab in people with Small Cell Lung Cancer (SCLC; a type of fast-growing cancer that forms in tissues of the lung and can spread to other parts of...
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NCT06841354
A Phase 3, Randomized, Open-label Study Comparing Efficacy and Safety of Sacituzumab Tirumotecan (sac-TMT, MK-2870) as a Monotherapy and in Combination with Pembrolizumab (MK-3475) Versus Treatment of Physician’s Choice in Participants With Previously Untreated Locally Recurrent Unresectable or Metastatic Triple-Negative Breast Cancer Expressing PD L1 at CPS Less than 10 (TroFuse 11)
This study is currently enrolling.Associated Conditions: BreastResearch Area: Clinical Cancer ResearchResearch Location: AltamonteThis trial is testing sacituzumab tirumotecan (sac-TMT) when given alone and with pembrolizumab (pembro) in people with triple negative breast cancer (TNBC). The trial will test these drugs in people...
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NCT05640999
A Phase II Study of Tailored Adjuvant Therapy in Pole-Mutated and p53-Wildtype/NSMP Early-Stage Endometrial Cancer (RAINBO BLUE & TAPER)
This study is currently enrolling.Associated Conditions: GynecologyResearch Area: Clinical Cancer ResearchResearch Location: Porter, ColoradoThis study is being done to answer the following question: Are there types of early-stage endometrial cancer that require less treatment than the usual approach? We are doing this study because we...
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NCT05256225
A Phase II/III Study of Paclitaxel/Carboplatin Alone or Combined with Either Trastuzumab and Hyaluronidase-oysk (HERCEPTIN HYLECTA) or Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf (PHESGO) in HER2 Positive, Stage I-IV Endometrial Serous Carcinoma or Carcinosarcoma
This study is currently enrolling.Associated Conditions: GynecologyResearch Area: Clinical Cancer ResearchResearch Location: Porter, Colorado