Paul M. Coen, PhD


Dr. Paul Coen is an Investigator at the Translational Research Institute for Metabolism and Diabetes, AdventHealth and an Adjunct Assistant Professor at the Center For Metabolic Origins of Disease,  Sanford•Burnham•Prebys Medical Discovery Institute (SBP-MDI) at Lake Nona.

Paul’s research program is focused on elucidating the role of skeletal muscle mitochondrial energetics in the pathophysiology’s associated with aging and obesity. The goal of his current NIH-supported project is to further understand how dysfunctional mitochondria and muscle lipid contribute to loss of muscle mass and strength (sarcopenia) and slower walking speed in older adults. Loss of muscle strength and slower walking speed are both important clinical parameters that can lead to mobility disability and loss of independence in older individuals. A second area of interest relates to the clinical importance of regular exercise following gastric bypass surgery. Few studies have objectively examined whether exercise following surgery-induced weight loss provides additive benefit in terms of weight loss, insulin sensitivity and metabolism.

Paul’s postdoctoral training was in the area of muscle metabolism under the mentorship of Dr. Bret Goodpaster at the University of Pittsburgh’s Division of Endocrinology and Metabolism (2008-2010). His postdoctoral work resulted in authorship on numerous peer-reviewed publications in high impact journals such as the Journal of Clinical Investigation, Diabetes, and Diabetes Care. Paul has been invited to talk at the American Diabetes Association annual meeting (2009, 2013), American College of Sports Medicine meeting (2011, 2014), The Obesity Society Annual Meeting (2013, 2015) and Cell Symposia on Exercise Metabolism (2015) and acts as an ad-hoc reviewer for many journals, including Diabetelogia, Obesity, International Journal of Obesity, Medicine and Science in Sports and Exercise, and the American Journal of Physiology.

Originally hailing from Dublin, Ireland, Paul made the jump across the pond to study for a PhD in Exercise Physiology at Purdue University, which he completed in 2008. Prior to this, he completed an M.S. in Vascular Biology at the Vascular Health Research Center (VHRC) at Dublin City University (2004), and received his initial didactic and laboratory-based training with a B.Sc. in Bioanalytical Science from the Institute of Technology, Tallaght, Ireland (2000).

Pubmed | ORCID | Scopus | Google Scholar | ResearchGate | Twitter

Selected Publications:

Exercise, Weight Loss and Bariatric Surgery

Coen P.M., Tanner C.J., Helbling H.L., Dubis G.S., Hames K.C., Hui X., Eid G.M., Stefanovic-Racic M., Toledo F.G.S., Jakicic J.M., Houmard J.A., Goodpaster B.H. (2015) Clinical Trial Demonstrates Exercise Following Bariatric Surgery Improves Insulin Sensitivity. J Clin Invest. 125(1):248-57.

Coen, P.M. and Goodpater, B.H. (2015) A Role For Exercise After Bariatric Surgery.  Diabetes Obes Metab (In press).

Coen P.M., Menshikova E.V., Distefano G., Zheng D., Tanner C.J., Standley R.A., Helbling N.L., Dubis G., Ritov R.B., Xie H., Desimone M.E., Smith S.R., Stefanovic-Racic M., Toldeo F.G.S., Houmard J.A., Goodpaster B.H. (2015) Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning and Insulin Sensitivity Following Gastric Bypass Surgery. Diabetes 64(11)3737-50.

Woodlief T.L., Carnero E.A., Standley R.A., Distefano G., Anthony S.J., Dubis G.S., Jakicic J.M., Houmard J.A., Coen P.M., Goodpaster B.H. (2015) Dose-Response of Exercise Training following Roux-en-Y Gastric Bypass Surgery: A Randomized Trial. Obesity (In press).

Dubé J.J., Amati F., Toledo F.G.S., Stefanovic-Racic M., Rossi A., Coen P.M., Goodpaster B.H. (2011) Effects of Weight Loss and Exercise on Insulin Resistance, and Intramyocellular Triacylglycerol, Diacylglycerol and Ceramide. Diabetologia. May;54(5):1147-56.

Skeletal Muscle Mitochondria and Ceramide in Insulin Resistance

Coen P.M., Hames K.C., Leachman E.M, Delany J.P., Ritov V.B., Menshikova E.V., Dubé J.J., Stefanovic-Racic M., Toledo F.G.S., Goodpaster B.H., (2013) Reduced Skeletal Muscle Oxidative Capacity and Elevated Ceramide but not Diacylglyceride Content in Severe Obesity. Obesity. Nov;21(11):2362-71.

Coen P.M., Goodpaster B.H. (2012) The Role of Intramyocellular Lipids in Human Health. Review in Trends Endocrinol Metab. Aug;23(8):391-8.

Amati F., Dube J.J., Alvarez-Carnero E., Edreira M.M., Chomentowski P., Coen P.M., Switzer G.E., Bickel P.E., Stefanovic-Racic M., Toledo F.G.S., Goodpaster B.H. (2011) Skeletal Muscle Triglycerides, Diacylglycerols and Ceramides in Insulin Resistance: Another Paradox in Endurance-trained Athletes? Diabetes. Oct;60(10):2588-97.

Chomentowski P., Coen P.M., Radikova Z., Goodpaster B.H., Toledo F.G.S. (2011) Skeletal Muscle Mitochondria in Insulin Resistance: Differences in Intermyofibrillar Versus Subsarcolemmal Subpopulations and Relationship to Metabolic Flexibility. J Clin Endocrinol Metab. Feb;96(2):494-503.

Coen P.M., Dube J.J., Amati F., Stefanovic-Racic M., Ferrell R.E., Toledo F.G., Goodpaster B.H. (2010) Insulin Resistance is Associated with Higher Intramyocellular Triglycerides in Type I but not Type II Myocytes Concomitant with Higher Ceramide Content. Diabetes. Jan;59(1):80-8.

Muscle Mitochondrial function in Older Adults

Santanasto A.J., Glynn N.W., Jubrias S.A., Conley K.E., Boudreau R.M., Amati F., Mackey D.C., Simonsick E.M., Strotmeyer E.S., Coen P.M., Goodpaster B.H., Newman A.B. (2015) Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults. J Gerontol A Biol Sci Med Sci. 70(11):1379-85

Coen P.M., Jubrias S.A., Distefano G., Amati F., Mackey D.C., Glynn N.W., Manini T.M., Wohlgemuth S.E., Leeuwenburgh C., Cummings S.R., Newman A.B., Ferrucci L., Toledo F.G.S., Shankland E., Conley K.E., Goodpaster B.H. (2013) Skeletal Muscle Mitochondrial Energetics are Associated with Maximal Aerobic Capacity and Walking Speed in Older Adults. J Gerontol A Biol Sci Med Sci. Apr;68(4):447-55.

Coen P.M.*, Conley K.E. (2013) Reduced Work Efficiency with Age without Change in Fiber Type. Comment on Point:Counterpoint: Skeletal Muscle Mechanical Efficiency Does/Does Not Increase with Age. Comment in J Applied Physiol. Apr;114(8):1114-8.

Distefano G., Standley, R.A., Dube J.J., Helbling N.L., Ritov V.B., Stefanovic-Racic M., Toledo F.G.S., Ng J., Goodpaster B.H., Coen P.M.* (2015) Human Skeletal Muscle Mitochondria Respiration: The Influence of Aging, Adiposity and Aerobic Fitness (In review at J Gerontol A Biol Sci Med Sci.)

Exercise and Inflammation

Stewart L.K., Flynn M.G., Campbell W.W., Craig B.A., Robinson J.P., McFarlin B.K., Timmerman K.L, Coen P.M., Felker J., and Talbert E. (2007) The Influence of Exercise Training on Inflammatory Cytokines and C-Reactive Protein. Med Sci Sports Exerc. Oct; 39(10):1714-9.

Timmerman K.L., Flynn M.G., Coen P.M., Markofski M.M., and Pence B. (2008) Exercise Training-induced Lowering of Inflammatory (CD14+CD16+) Monocytes: A Role in the Anti-inflammatory Influence of Exercise? J Leukoc Biol. Nov; 84 (5): 1271-8.

Coen P.M.*, Flynn M.G., Markofski M.M., Pence B.D., Hannemann R.E.  (2009) Adding Exercise Training to Rosuvastatin Treatment: Influence on Serum Lipids and Biomarkers of Muscle and Liver Damage. Metabolism. May 1. Jul; 58(7): 1030-8.

Coen P.M.*, Flynn M.G., Markofski M.M., Pence B.D., Hannemann R.E.  (2010) Adding Exercise to Rosuvastatin Treatment: Influence on C-reactive Protein, Monocyte Toll-like Receptor 4 Expression, and Inflammatory Monocyte (CD14+CD16+) Population. Metabolism. Dec;59(12):1775-83.

Markofski M.M., Carrillo A.E., Timmerman K.L., Jennings K., Coen P.M., Pence B.D., Flynn M.G. (2014) Exercise Training Modifies Ghrelin and Adiponectin Concentrations and is Related to Inflammation in Older Adults. J Gerontol A Biol Sci Med Sci. Jun;69(6):675-81. 

* Corresponding Author