Karen D. Corbin, PhD, RD

Investigator

Dr. Corbin is an Investigator at the Translational Research Institute of Metabolism and Diabetes. Her program of research focuses on enterohepatic metabolism and the mechanisms that drive individual susceptibility to metabolic diseases such as non-alcoholic fatty liver disease, diabetes and obesity. The specific mechanisms she is investigating include whole body energy balance, novel circulating, genetic and tissue biomarkers, advanced non-invasive hepatic imaging methodologies, the gut microbiome, and nutritionally-relevant signaling pathways.

Dr. Corbin comes to the TRI after a 3-year term as a Research Assistant Professor at UNC Chapel Hill, Gillings School of Global Public Health, Department of Nutrition. She conducted both her faculty and post-doctoral research at the UNC Nutrition Research Institute in Kannapolis, NC. Her research program was dedicated to understanding individual differences nutrient requirements. Her goal was to understand how these differences influenced metabolic diseases such as obesity, diabetes and fatty liver. Her studies focused on choline and betaine, two nutrients known to modulate metabolic phenotypes. Dr. Corbin’s research spanned the translational research continuum, from mechanistic studies performed at the laboratory bench, to population studies and clinical trials designed to translate her findings into human populations. Dr. Corbin utilized a combination of classic molecular biology approaches, controlled feeding studies, and innovative phenotyping tools, including whole room calorimetry, transient elastography, body composition, genomics, metabolomics, and microbiome profiling.

Dr. Corbin earned her doctorate degree in molecular medicine at the University of South Florida College of Medicine in 2008. She became a registered dietitian in 1998 after completing her dietetic internship at the James A. Haley Veteran’s Hospital in Tampa, FL. She earned her Bachelor’s Degree in Nutrition and Food Science in 1997 at Florida State University.

Publications:

Peer-Reviewed Articles

Patel NA, Kaneko S, Apostolatos HS, Bae SS, Watson JE, Davidowitz K, Chappell DS, Birnbaum MJ, Cheng JQ, Cooper DR. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase C betaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. J Biol Chem 2005; 280:14302-14309

Goodwin BL, Corbin KD, Pendleton LC, Levy MM, Solomonson LP, Eichler DC. Troglitazone up-regulates vascular endothelial argininosuccinate synthase. Biochem Biophys Res Commun 2008; 370:254-258

Corbin KD, Pendleton LC, Solomonson LP, Eichler DC. Phosphorylation of argininosuccinate synthase by protein kinase A. Biochem Biophys Res Commun 2008; 377:1042-1046

Knab AM, Shanely RA, Corbin KD, Jin F, Sha W, Nieman DC. A 45-minute vigorous exercise bout increases metabolic rate for 14 hours. Med Sci Sports Exerc 2011; 43:1643-1648

Haines RJ, Corbin KD, Pendleton LC, Eichler DC. Protein kinase Calpha phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem 2012; 287:26168-26176

Haines RJ, Corbin KD, Pendleton LC, Meininger CJ, Eichler DC. Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. Biochem Biophys Res Commun 2012; 421:9-14

Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH. Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB J 2013; 27:1674-1689

O’Connor A, Corbin KD, Nieman DC, Swick AG. A randomized, controlled trial to assess short-term black pepper consumption on 24-hour energy expenditure and substrate utilization. Functional Foods in Health and Disease 2013; 3:377-388.

da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. FASEB J 2014; 28:2970-2978

May PA, Hamrick KJ, Corbin KD, Hasken JM, Marais AS, Brooke LE, Blankenship J, Hoyme HE, Gossage JP. Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa. Reprod Toxicol 2014; 46:31-39

Miller CA, Corbin KD, da Costa KA, Zhang S, Zhao X, Galanko JA, Blevins T, Bennett BJ, O'Connor A, Zeisel SH. Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Am J Clin Nutr 2014; 100:778-786

Lupu DS, Cheatham CL, Corbin KD, Niculescu MD. Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part I: maternal FADS2 genotype and DNA methylation correlate with polyunsaturated fatty acid status in toddlers: an exploratory analysis. Nutr Res 2015; 35:939-947

Silver MJ, Corbin KD, Hellenthal G, da Costa KA, Dominguez-Salas P, Moore SE, Owen J, Prentice AM, Hennig BJ, Zeisel SH. Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. FASEB J 2015; 29:3426-3435

May PA, Hamrick KJ, Corbin KD, Hasken JM, Marais AS, Blankenship J, Hoyme HE, Gossage JP. Maternal nutritional status as a contributing factor for the risk of fetal alcohol spectrum disorders. Reprod Toxicol 2016; 59:101-108
 

Book Chapters and Reviews

Corbin KD. Metabolic Syndrome, Obesity, and Diabetes. In Nutrition and Epigenetics, Volume 1, Niculescu M. and Haggarty P, eds. (Ames, Iowa: Wiley-Blackwell), 2011; pp. 145-164.

Corbin KD, and Zeisel SH. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol 2012; 28:159-165.

Corbin KD, and Zeisel SH. The nutrigenetics and nutrigenomics of the dietary requirement for choline. Prog Mol Biol Transl Sci 2012; 108:159-177.

Zeisel SH, Corbin KD. Choline. In Present Knowledge In Nutrition, Volume 10, J.W. Erdman, I.A. MacDonald and S.H. Zeisel, eds. (Ames, Iowa: Wiley-Blackwell) 2012.

Driscoll KA, Corbin KD, Maahs DM, Pratley R, Bishop FK, Kahkoska A, Hood KK, Mayer-Davis E. Biopsychosocial Aspects of Weight Management in Type 1 Diabetes: a Review and Next Steps. Curr Diab Rep 2017; 17:58.

Corbin KD, Driscoll KA, Pratley RE, Smith SR, Maahs DM, Mayer-Davis, EJ, on behalf of the Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON). Obesity in Type 1 Diabetes: Impact, Physiology and Mechanisms. Endocrine Revews. Under Revision 2/9/2018.

 

Full Bibliography at PubMed