Translational Research Clinical Trials
Search our team at AdventHealth Research Institute
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Determining cell- and spatially-distinct skeletal muscle transcriptional aberrations in insulin resistance
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: The purpose of this study is to look at gene expression changes to insulin stimulation in different cells and areas of skeletal muscle and how they are affected by obesity and insulin...
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NCT05390892
PREvention of CardIovascular and DiabEtic KidNey Disease in Type 2 Diabetes
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: 2.1. Objective The primary objective of PRECIDENTD is to compare rates of the total number of important cardiovascular, kidney, and death events among two alternative treatments for... -
NCT06217302
Effectiveness and safety of Sotagliflozin in slowing kidney function decline in persons with type 1 diabetes and moderate to severe diabetic kidney disease: The SUGARNSALT Trial
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: The purpose of this study is to find out if a drug called sotagliflozin (SOTA) can slow kidney function decline in persons with type 1 diabetes and moderate to severe diabetic kidney...
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NCT07052942
Individualizing Treatment for Asthma in Primary Care (iTREAT-PC)
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoiTREAT Study Purpose: The purpose of this study is to compare the safety and effectiveness of two different ways to treat asthma. The first way is adding inhaled corticosteroids to your rescue... -
NCT07184086
The effect of cagrilintide and semaglutide combination treatment compared to a weight-loss inducing diet on energy metabolism in persons living with obesity: an open-label randomised study
This study is currently enrolling.Associated Conditions: Obesity & MetabolismResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: The purpose of this study is to provide insight into the effect of Cagrisema on energy metabolism compared with low energy diet alone.
To be enrolled in this study, you must meet...
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SOMMA2: Study of Muscle, Mobility and Aging
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Translational ResearchResearch Location: OrlandoThe goal of SOMMA is to better understand why some people lose muscle strength and mobility as they get older and how this might lead to difficulties with everyday activities. SOMMA is a national... -
NCT06325202
Closed Loop and Education for hypoglycemia Awareness Restoration (CLEAR)
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoCLEAR Study Purpose: blood sugar has weakened. This research study will use different types of education and devices to see if they can help you feel when your blood glucose is low.
Study Duration... -
NCT06993454
ACELERATE-P: Acute exercise and endogenous glucose production in type 2 diabetes: Implications for glycemic control and treatment of hepatic steatosis. The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by your liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: To investigate the effects of exercise on the amount of glucose that is made by your liver in people with Type 2 diabetes (T2D) and fatty liver and those without. Study Duration: 4... -
NCT06602141
ATLAS: Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise
This study is currently enrolling.Associated Conditions: Obesity & MetabolismResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin resistance in people with obesity. To be enrolled... -
NCT05984238
RECET: A Multicenter, Double-blind, Sham-controlled Study for Assessing the Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals with Type 2 Diabetes
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: To study changes in blood glucose control and weight loss in Type II Diabetics using Nutrition and Lifestyle Counseling combined with an investigational device called the ReCET... -
ENABLE: Clinical validation of islet autoantibody measurement in self-collected dried blood spot specimens
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: Clinical validation of islet autoantibody measurement in self-collected dried blood spot specimens. To be enrolled in this study, you must meet certain requirements. You may be... -
NCT05197920
DREAM: Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM). An observational cohort study from the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: The purpose of this research study is to find out how many people with acute pancreatitis develop diabetes. Risk factors for diabetes and the types of diabetes that occur after acute...