Translational Research Clinical Trials
Search our team at AdventHealth Research Institute
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NCT07281495
REV-OBESITY: A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Study with Open-Label Extension to Assess the Efficacy, Safety, and Pharmacokinetics of Subcutaneously Administered Taldefgrobep alfa in Adults Living with Overweight and Obesity.
This study is currently enrolling.Associated Conditions: Obesity & MetabolismResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: Learn about the efficacy, safety, and tolerability of taldefgrobep as a potential treatment for weight management in adults living with overweight/obesity, and to better understand how...
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NCT07184086
The effect of cagrilintide and semaglutide combination treatment compared to a weight-loss inducing diet on energy metabolism in persons living with obesity: an open-label randomised study
This study is currently enrolling.Associated Conditions: Obesity & MetabolismResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: The purpose of this study is to provide insight into the effect of Cagrisema on energy metabolism compared with low energy diet alone.
To be enrolled in this study, you must meet...
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SOMMA2: Study of Muscle, Mobility and Aging
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Translational ResearchResearch Location: OrlandoThe goal of SOMMA is to better understand why some people lose muscle strength and mobility as they get older and how this might lead to difficulties with everyday activities. SOMMA is a national...
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NCT06745284
An active-comparator-controlled, open-label, parallel group study to evaluate the effect of survodutide on energy expenditure and fatty acid oxidation in subjects with obesity
This study is currently enrolling.Associated Conditions: Obesity & MetabolismResearch Area: Translational ResearchResearch Location: OrlandoA study to test whether survodutide improves how the body uses energy and breaks down fat in people with obesity.
To be enrolled in this study, you must meet certain requirements. You may be eligible...
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NCT06993454
ACELERATE-P: Acute exercise and endogenous glucose production in type 2 diabetes: Implications for glycemic control and treatment of hepatic steatosis. The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by your liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: To investigate the effects of exercise on the amount of glucose that is made by your liver in people with Type 2 diabetes (T2D) and fatty liver and those without.
Study Duration: 4... -
NCT06602141
ATLAS: Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise
This study is currently enrolling.Associated Conditions: Obesity & MetabolismResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin resistance in people with obesity.
To be enrolled...
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NCT05984238
RECET: A Multicenter, Double-blind, Sham-controlled Study for Assessing the Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals with Type 2 Diabetes
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: To study changes in blood glucose control and weight loss in Type II Diabetics using Nutrition and Lifestyle Counseling combined with an investigational device called the ReCET...
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ENABLE: Clinical validation of islet autoantibody measurement in self-collected dried blood spot specimens
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: Clinical validation of islet autoantibody measurement in self-collected dried blood spot specimens.
To be enrolled in this study, you must meet certain requirements. You may be...
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NCT06008977
EX-BOOST: Exercise to boost response to checkpoint blockade immunotherapy
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: To obtain a better understanding on how exercise can improve outcomes for patients with skin cancers.
To be enrolled in this study, you must meet certain requirements. You may be...
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COMET: ImpaCt Of shiftwork on METabolic Flexibility and Skeletal Muscle Clocks.
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: To determine how working a nighttime shift impacts your metabolism.
To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you meet the...
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NCT05197920
DREAM: Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM). An observational cohort study from the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoStudy Purpose: The purpose of this research study is to find out how many people with acute pancreatitis develop diabetes. Risk factors for diabetes and the types of diabetes that occur after acute...
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NCT00097292
TRIALNET: Natural History Study of the Development of Type 1 Diabetes
This study is currently enrolling.Associated Conditions: DiabetesResearch Area: Translational ResearchResearch Location: OrlandoYou are being asked to be in a research study called the TrialNet Natural History Study of the Development of Type 1 Diabetes. As you know, TrialNet is an international research group dedicated to the...