Guru Sonpavde, MD
Medical Director (Urology), Medical Oncologist
Research Area:
Expertise of Guru Sonpavde, MD
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- Biography
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Guru P. Sonpavde, MD serves as the Medical Director of Genitourinary (GU) Oncology and the Phase I Clinical Research Unit and Christopher K. Glanz Chair for Bladder Cancer Research () at the AdventHealth Cancer Institute (List of active Phase I trials here: Search for: In Celebration, FL, Recruiting studies, Phase: 1 | Card Results | ClinicalTrials.gov). Previously, he was Bladder Cancer Director at the Dana-Farber Cancer Institute and Associate Professor of Medicine at Harvard Medical School from 2017-2022, GU Oncology Director and Associate Professor of Medicine at the University of Alabama at Birmingham from 2012 to 2017 and practiced from 2004 to 2012 at Texas Oncology. Dr. Sonpavde’s focus is drug development and translational research to cure GU cancers, which have led to approximately 500 publications (sonpavde - Search Results - PubMed). In addition to his expertise in Urologic Medical Oncology, he also conducts Phase I clinical trials. He is a member of Southwest Oncology Group, Scientific Advisory Board of the Bladder Cancer Advocacy Network (BCAN), and the Bladder Cancer Task Force of U.S. NCI GU Steering Committee. He was cited in TIME magazine regarding his participation in clinical trials in August 2022 (Clinical Trials for Bladder Cancer | TIME).”
- Education
University of Madras
- Residency
Internal Medicine at Nassau County Medical Center
- Fellowship
Hematology & Oncology at Indiana University School of Medicine
- Board Certifications
Medical Oncology: The American Board of Internal Medicine
Internal Medicine: The American Board of Internal Medicine
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Publications of Guru Sonpavde, MD
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Vaccine approaches to treat urothelial cancer, HUMAN VACCINES & IMMUNOTHERAPEUTICS
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Impact of Angiotensin Converting Enzyme Inhibitors on Pathologic Complete Response With Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer, CLINICAL GENITOURINARY CANCER
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Evaluation of American Joint Committee on Cancer and alternative tumour classification systems for primary penile squamous cell carcinoma, BRITISH JOURNAL OF DERMATOLOGY
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New Therapeutic Horizons for Advanced or Metastatic Penile Cancer, UROLOGIC CLINICS OF NORTH AMERICA
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Factors predictive of recurrence, metastasis and death in node-negative penile squamous cell carcinoma: A retrospective multicentre cohort study, JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
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The evolving treatment landscape of metastatic urothelial cancer, NATURE REVIEWS UROLOGY
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Clinical outcomes and safety of immune checkpoint inhibitors in patients with solid tumors and paraneoplastic syndromes, JOURNAL FOR IMMUNOTHERAPY OF CANCER
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Unlocking precision oncology with FGFR inhibition in urothelial carcinoma, ANNALS OF ONCOLOGY
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Comprehensive multiplexed autoantibody profiling of patients with advanced urothelial cancer, JOURNAL FOR IMMUNOTHERAPY OF CANCER
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Circulating tumor DNA as a Predictive and Prognostic Biomarker in the Perioperative Treatment of Muscle-invasive Bladder Cancer: A Systematic Review, EUROPEAN UROLOGY ONCOLOGY
Associated Clinical Trials for Guru Sonpavde, MD
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NCT07223125
A Phase 1 Study of JNJ-89862175, an Antibody Drug Conjugate (ADC) Agent Targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 (ENPP3), for Advanced Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationA Phase 1 Study of JNJ-89862175, an Antibody Drug Conjugate (ADC) Agent Targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 (ENPP3), for Advanced Solid Tumors -
NCT06803680
A Phase 1, Open-Label Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-B455 in Patients With Selected Advanced or Metastatic Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purpose of this study is to test if the study drug BGB-B455, when it is given on its own, is safe and tolerated in patients with solid tumors expressing the CLDN6 protein. -
NCT05929235
A Phase 1, First-in-Human, Dose-Escalation and Expansion Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationMore clinical trials loaded
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NCT06660654
A Phase 2, Multicenter, Open-Label, Pan-Tumor Trial to Evaluate Efficacy and Safety of Raludotatug Deruxtecan (R-DXd) in Participants with Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01)
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purpose of this research is to learn more about and investigational drug called raludotatug deruxtecan, hereafter referred to as D-DXd. it is being studies to see if it is effective, tolerable... -
NCT06635785
Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors (BiPAVE-001)
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe main purpose of the study is to determine whether the experimental study drug, AI-081, is safe and well tolerated, and whether it is effective in treating advanced or metastatic cancer. -
NCT06352359
Safety, Pharmacokinetics (PK), and Efficacy of ONC-841 in Advanced Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThis is a research study to find out if an experimental drug called ONC-841 is safe and effective in cancer patients and how the drug is absorbed and processed in the body of patients with cancer. ONC... -
NCT06172478
A Phase 2, Multicenter, Multicohort, Open-Label, Proof of Concept Study of Patritumab Deruxtecan (HER3-DXd; U3-1402) in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purpose of this study is to learn more about an investigational drug called patritumab deruxtecan (also known as HER3-DXd or U3-1402), also referred to as “study drug” or “study treatment”... -
NCT06589596
BGB-58067-101: A Phase 1a/b Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-58067, an MTA-Cooperative PRMT5 Inhibitor in Patients With Advanced Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purpose of this study is to test if study drug (BGB-58067) is safe and tolerable, test how your body processes the study drug, and test if it works in patients with advanced solid tumor who have... -
rhPSMA-7.3(18F)-PET scan to detect prostate cancer in patients with early PSA recurrence.
This study is currently enrolling.Associated Conditions: GenitourinaryResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe research is being done at the Radiology Nuclear Medicine Department of AdventHealth Orlando and Celebration. Patients are instructed to drink water prior to administration of flotufolastat F-18 to... -
NCT05987241
MODERN: An Integrated Phase 2/3 and Phase 3 Trial of MRD-Based Optimization of ADjuvant ThErapy in URothelial CaNcer A032103
This study is currently enrolling.Associated Conditions: GenitourinaryResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis study is being done to answer the following question: After having your bladder surgically removed after being diagnosed with bladder cancer, can we better identify which patients need an... -
NCT06307795
A Phase 1 study evaluating the safety, tolerability, pharmacokinetics, and preliminary efficacy of ANS014004 as a single agent in participants with locally advanced or metastatic solid tumors.
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThis is a Phase 1, first-in-human, open-label, multi-center study with the aim of exploring the safety, tolerability, PK, and preliminary anti-tumor activity of ANS014004 as a single agent in... -
NCT06318273
A Phase 1 First-in-Human Study Evaluating Safety, Pharmacokinetics, and Efficacy of ABBV-969 in Adult Subjects With Metastatic Castration-Resistant Prostate Cancer
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purpose of this study is to see if the study drug is safe and tolerable. This study will consist of 2 main phases: dose escalation (Part 1) and dose expansion (Part 2). In Part 1, multiple... -
NCT06238479
A Phase 1 Trial Investigating LY4101174, an Antibody-Drug Conjugate Targeting Nectin-4, in Participants with Recurrent, Advanced or Metastatic Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationYou are being invited to take part in this study because you have been diagnosed with a type of cancer that may express a protein called nectin-4, which LY4101174 is designed to treat and you have... -
NCT05914116
A Phase 1/2a, Multicenter, Open-Label, First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of DB-1311 in Subjects with Advanced/Metastatic Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe main goal of this study is to test whether the study drug is safe and tolerable in patients with advanced/unresectable, or metastatic solid tumors (including small cell lung cancer, non-small cell... -
NCT06631521
Neoadjuvant Darolutamide and Relugolix combination preceding radical prostatectomy for high risk localized and locally advanced prostate cancer: a Phase I/Ib trial
This study is currently enrolling.Associated Conditions: GenitourinaryResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe primary study objective is to determine the safety and feasibility of a new combination of darolutamide and relugolix as neoadjuvant therapy preceding radical prostatectomy (RP) for high-risk... -
NCT06305767
A Phase 2, Randomized, Double-blind Study of Adjuvant V940 (mRNA-4157) + Pembrolizumab (MK-3475) vs. Placebo + Pembrolizumab for High-Risk Muscle-Invasive Urothelial Carcinoma (MIUC) Post-Radical Resection
This study is currently enrolling.Associated Conditions: GenitourinaryResearch Area: Clinical Cancer ResearchResearch Location: OrlandoTo compare V940 plus pembrolizumab to placebo plus pembrolizumab with respect to DFS. Hypothesis (H1): V940 plus pembrolizumab is superior to placebo plus pembrolizumab with respect to DFS as assessed... -
NCT05592626
CP-START-001: A Phase 1/2, First-in-Human, Open-Label, Dose Escalation and Expansion Study of STAR0602, a Selective T Cell Receptor (TCR)-targeting, Bifunctional Antibody-fusion Molecule, in Subjects with Unresectable, Locally Advanced, or Metastatic Solid Tumors that are Antigen-rich (START-001)
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purpose of this research study is To test the safety of study drug STAR0602. To see how well different doses of the study drug STAR0602 are tolerated in different groups of patients. To understand... -
NCT06026410
KO-2806-001: Phase 1, First-in-Human, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of KO-2806 When Administered as Monotherapy and in Combination Therapy in Adult Patients with Advanced Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purposes of this study are to: • Determine the highest tolerable dose of KO-2806 given orally (by mouth) in combination with cabozantinib. • Determine whether KO-2806 has an antitumor effect... -
NCT05948865
A Phase 1, Multicenter, Single Agent Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of CPO301, an EGFR-Targeting Antibody-Drug Conjugate, in Adult Patients with Advanced or Metastatic Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purpose of the study, called CPO301-US-101, is to see if CPO301 (also known as SYS6010) is safe and effective in treating your type of cancer when administered as an intravenous (administered into... -
NCT05614739
AN OPEN-LABEL, MULTICENTER STUDY OF LOXO-435 (LY3866288) IN ADVANCED SOLID TUMOR MALIGNANCIES WITH FGFR3 ALTERATIONS
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationAN OPEN-LABEL, MULTICENTER STUDY OF LOXO-435 (LY3866288) IN ADVANCED SOLID TUMOR MALIGNANCIES WITH FGFR3 ALTERATIONS -
NCT05176483
A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination with Immuno-Oncology Agents in Subjects with Unresectable Advanced or Metastatic Solid Tumors (STELLAR-002)
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationYou are being asked to take part in a clinical research study called STELLAR-002 because you have been diagnosed with cancer or your cancer has worsened since your last treatment. If you join this... -
NCT04724018
Combinatons of Sacituzumab govitecan plus enfortumab vedotin and pembrolizumab for metastatic urothelial carcinoma: the Double Antibody Drug conjugate (DAD) and Double Antibody Drug Conjugate with Immunotherapy (DAD-IO) Phase I/II trial
This study is not currently enrolling.Associated Conditions: GenitourinaryResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis research is being done to study the safety and efficacy of two drug combinations. The first combination is Sacituzumab govitecan and enfortumab vedotin, and the second is Sacituzumab govitecan in... -
NCT05514717
A Phase 1, First-in-Human, Dose Escalation and Expansion, Multicenter Study of XMT-2056 in Participants with Advanced/Recurrent Solid Tumors that Express HER2
This study is not currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: Celebration -
NCT06253130
EIK1003-001 (IMP1734-101): A first-in-human, Phase 1/2, open-label, multi-center, dose escalation, dose-optimization, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of PARP1 selective inhibitor, IMP1734, in patients with advanced solid tumors
This study is not currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe study treatment is IMP1734, which is an experimental drug which means that regulatory authorities have allowed the study to be tested in this clinical trial for its potential to treat cancers in... -
NCT04669899
Phase 1 First-in-Human Study of Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) Inhibitor Monoclonal Antibody (mAb) JTX8064, as Monotherapy and in Combination with a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, in Adult Subjects with Advanced Refractory Solid Tumor Malignancies
This study is not currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationA medical research study for participants who have been diagnosed with a solid tumor (i.e. cancer) and currently, the tumor is unresponsive to approved treatments, approved treatments are worsening...