Clinical Trials
Search our team at AdventHealth Research Institute
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NCT06639958
Risk-Based 6MP Adherence Enhancement Strategies in Children, Adolescent and Young Adults With ALL - A Pilot Study Study Sponsor: Children’s Oncology Group
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoThis study is being done to answer the following question: Can we help children, adolescents and young adults with ALL to remember to take their daily Maintenance medicine, 6MP, at home? We are doing...
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NCT05675410
A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy with Immuno-oncology Therapy for Children and Adults with Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando -
NCT03067181
A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoLow Risk Subjects (Age <50 Years): The overall goal is to see if monitoring subjects with low risk germ cell tumors after their tumor is removed is as effective as following surgery with chemotherapy...
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NCT06172296
A Phase 3 Study of Dinutuximab Added to Intensive Multimodal Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoThe overall goals of this study are to
Compare the outcomes of dinutuximab given early with Induction therapy to the effects of standard Induction therapy with the addition of dinutuximab later in... -
NCT05761171
AALL2121: A Phase 2 Study of SNDX-5613 in Combination with Chemotherapy for Patients with Relapsed or Refractory KMT2A-Rearranged Infant Leukemia
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoThe overall goal of this study is to determine the safety and best dose of the drug SNDX-5613 for young children when given in combination with chemotherapy, and to see if this treatment will improve...
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NCT05602194
A Randomized Trial of Levocarnitine Prophylaxis to Prevent Asparaginase-Associated Hepatotoxicity in Adolescents and Young Adults Receiving Acute Lymphoblastic Leukemia Therapy
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoThe overall goal of this study is to determine whether adding levocarnitine to standard of care ALL treatment will reduce the chances of developing severe liver damage from asparaginase chemotherapy.
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NCT02582697
Phase 3 Accelerated BEP Trial: A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumors.
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando -
NCT04166409
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoThis study looks at how well a drug called selumetinib works when given to children and young adults with LGG. The study doctors want to see if selumetinib works as well as CV for getting rid of or...
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NCT03959085
A Phase 3 Randomized Trial of INotuzumab Ozogamicin (IND#: 133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoDisseminated B-Cell Lymphoblastic Lymphoma (B-LLy): The overall goal of this study is to determine the outcomes of subjects with disseminated B-LLy receiving High Risk B-cell Acute Lymphoblastic...
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NCT02981628
A Phase 2 Study of INotuzumab Ozogamicin (NSC# 772518, IND #133494) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoThe overall goal of this study is to find out what effect, good and/or bad, the drug inotuzumab ozogamicin has on children and young adults with relapsed or refractory B-ALL.
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NCT02402244
The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Pediatric Research and Clinical TrialsResearch Location: OrlandoWe are doing this study to find better ways to diagnose, treat and prevent cancers in children, adolescents and young adults. To do this, we need to learn more about cancers that happen to children...
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NCT04836390
A Phase II Pilot Study of Donor-Derived Ex-VivoExpanded Natural Killer Cell Infusions in Childrenand Young Adults with High-Risk Acute Myeloid Leukemia Receiving Myeloablative HLA Haploidentical Hematopoietic Cell Transplant: A Multicenter Pediatric Transplantation and Cellular Therapy Consortium (PTCTC) Study (EXCEL Trial) PTCTC CT2001.
This study is currently enrolling.Associated Conditions: Pediatric OncologyResearch Area: Clinical Cancer ResearchResearch Location: OrlandoParticipants will be invited to join this study if they have a blood disease called acute myeloid leukemia (AML) and it has been decided that they need a transplant as part of their treatment plan....