Clinical Trials
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Showing 1 - 12 of 15 clinical trials matching your search
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A Lifetime Partnership with Patients Who Have or May be at Risk of Having Cancer (Lungs)
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: OrlandoWe are asking to study your blood, bone marrow samples, tissues and other body fluids and any parts that make up these tissues, along with your clinical records and survey information. We are building... -
NCT05654922
A Phase 3, Open-Label, Randomized, Standard of Care- Controlled, Parallel Arm Study to Demonstrate Efficacy and Safety of ARINA-1 in the Prevention of Bronchiolitis Obliterans Syndrome Progression in Participants with Bilateral Lung Transplant
This study is currently enrolling.Associated Conditions: LungResearch Area: Transplant ResearchResearch Location: OrlandoThe purpose of this research study is to see if the investigational drug, ARINA-1 when used with the investigational PARI eFlow nebulizer system, can stabilize or improve the lung function of... -
NCT05671510
PRESERVE-003: Phase 3, Two-stage, Randomized Study of ONC-392 Versus Docetaxel in Metastatic Non-Small Cell Lung Cancers that Progressed on PD-1/PD-L1 Inhibitors
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe main purpose of the study is to determine whether the study drug, ONC-392, is safe and well tolerated, and whether it is effective in treating lung cancer, in comparison with a standard of care... -
NCT05498428
A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple Regimens in Patients with Advanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe investigational anti-cancer drugs being studied are called amivantamab (JNJ-61186372) and lazertinib (JNJ-73841937). They are being developed for the treatment of locally advanced or metastatic (i... -
NCT05211895
A Phase 3, Randomized, Double blind, Placebo controlled, Multicentre, International Study of Durvalumab and Domvanalimab (AB154) as Sequential Therapy in Participants with Locally Advanced (Stage III), Unresectable Non-small Cell Lung Cancer Whose Disease has not Progressed Following Definitive, Platinum-based Concurrent Chemoradiation Therapy (PACIFIC 8)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis study is being carried out in stage III NSCLC which cannot be removed by surgery. In this study, we will identify the effectiveness and safety of a possible treatment combination – durvalumab... -
NCT06203210
A Phase 3, Multicenter, Randomized, Open-label Study of Ifinatamab Deruxtecan (I-DXd), a B7-H3 Antibody Drug Conjugate (ADC), Versus Treatment of Physician’s Choice (TPC) in Subjects with Relapsed Small Cell Lung Cancer (SCLC)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoTo compare the efficacy of I-DXd with that of TPC, as measured by ORR per BICR and OS, in subjects with relapsed SCLC. -
NCT06767514
A Randomized, Double-blinded, Multiregional Phase 3 Study of Ivonescimab Versus Pembrolizumab for the First-line Treatment of Metastatic Non-small Cell Lung Cancer in Patients Whose Tumors Demonstrate High PD-L1 Expression (TPS greater than or equal to 50%)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this research is to measure the safety and effectiveness of ivonescimab compared to pembrolizumab. Ivonescimab is an antibody designed to block proteins that help cancer cells grow and... -
NCT05142696
A Phase Ib/II Dose Finding Study Assessing Safety and Efficacy of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Extensive Stage Small Cell Lung Cancer (ES-SCLC) in Combination With Carboplatin, Etoposide, and Atezolizumab in Induction and With Atezolizumab in Maintenance Phase
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this part of the study is to evaluate safety of Lutathera in patients with extensive stage small cell lung cancer (ES-SCLC) and to find the recommended dose of Lutathera in combination... -
NCT05946629
A Prospective Randomized Single-Blind Multicenter Study to Assess the Safety and Effectiveness of the SELUTION SLR 014 PTCA Drug Eluting Balloon in the Treatment of Subjects with De Novo Coronary Lesions in Small Vessels
This study is currently enrolling.Associated Conditions: CardiologyResearch Area: Heart, Lung and Vascular ResearchResearch Location: OrlandoThe purpose of the study is to determine whether the SELUTION SLR™ drug eluting balloon is safe and whether it works as effectively as other currently available treatments for patients with de novo...
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NCT05932615
Evaluation of the Navitor Transcatheter Heart Valve in Low and Intermediate Risk Patients who have Severe, Symptomatic, Aortic Stenosis Requiring Aortic Valve Replacement
This study is currently enrolling.Associated Conditions: Structural HeartResearch Area: Heart, Lung and Vascular ResearchResearch Location: OrlandoAortic stenosis is a type of heart valve disease where the valve located between the lower left heart chamber and the body’s main artery (aorta) becomes narrowed and cannot open completely. This... -
NCT05677100
DiuRetics Alone vs. AortIx ENdovascular Device for Acute Heart Failure (DRAIN HF)
This study is currently enrolling.Associated Conditions: Heart FailureResearch Area: Heart, Lung and Vascular ResearchResearch Location: TampaENROLLING IN TAMPA The purpose of this research is to evaluate the investigational Aortix System. The Aortix System is not approved by the FDA. The system has been designed for use in patients... -
NCT05685303
ALLAY-HF: Safety and Efficacy of the Alleviant System for No-Implant Interatrial Shunt Creation in Patients with Chronic Heart Failure
This study is currently enrolling.Associated Conditions: Heart FailureResearch Area: Heart, Lung and Vascular ResearchResearch Location: OrlandoTo evaluate the safety and efficacy of the Alleviant ALV1 System in patients with chronic heart failure (HF) and preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF), who...