Clinical Trials
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Showing 1 - 11 of 11 clinical trials matching your search
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Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders.
This study is currently enrolling.Associated Conditions: Interventional EndoscopyResearch Area: Digestive Health and SurgeryResearch Location: OrlandoThird space endoscopy, commonly referred as submucosal endoscopy, is founded on the principle that the deeper layers of the gastrointestinal (GI) tract can be accessed by tunneling in the submucosal... -
NCT06951490
Evaluating the Predictive Value of a Negative PillSense Result for Safe Discharge in Hospitalized Patients with Positive Hemoccult Tests and/or Anemia Without Overt Gastrointestinal Bleeding.
This study is currently enrolling.Associated Conditions: GI / HepatologyResearch Area: Digestive Health and SurgeryResearch Location: OrlandoThis research is being conducted to address the challenges associated with the current diagnostic approach for hospitalized patients with anemia, and/or positive stool-based study for occult... -
NCT06459869
A multicentre, open label, non-randomized, phase 1b trial of NG-350A, a tumourselective anti-CD40-expressing adenoviral vector, in combination with chemoradiotherapy in locally advanced rectal cancer (FORTRESS)
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this research is to test an investigational drug called NG-350A as a possible treatment for locally advanced rectal cancer (LARC). An investigational drug is one that has not been... -
NCT06662786
A Randomized, Open-label Phase 3 Study of Amivantamab + mFOLFOX6 or FOLFIRI Versus Cetuximab + mFOLFOX6 or FOLFIRI as First-line Treatment in Participants with RAS/RAF Wild-Type Unresectable or Metastatic Left-sided Colorectal Cancer (OrigAMI-2)
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: AltamonteThe purpose of this study is to compare the effects of two anticancer drugs (amivantamab and cetuximab) when each is given in combination with standard colorectal cancer (CRC) chemotherapies. to... -
NCT06750094
A Randomized, Open-label Phase 3 Study of Amivantamab + FOLFIRI Versus Cetuximab/Bevacizumab + FOLFIRI in Participants with KRAS/NRAS and BRAF Wild-type Recurrent, Unresectable or Metastatic Colorectal Cancer Who Have Received Prior Chemotherapy
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this study is to compare the effects of amivantamab in combination with standard of care chemotherapy (FOLFIRI) against cetuximab or bevacizumab in combination with FOLFIRI in... -
NCT06203600
Randomized Phase II/III Trial of 2nd Line Nivolumab + Paclitaxel + Ramucirumab versus Paclitaxel + Ramucirumab in Patients with PD-L1 CPS ? 1 Advanced Gastric and Esophageal Adenocarcinoma (PARAMUNE)
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis study is being done to answer the following questions: Can adding a drug to the usual treatment for advanced stomach and esophageal cancers make it less likely that these cancers will grow or... -
NCT06346392
D9802C00001 (CLARITY GC01): A Phase III Multi-center, Open-label, Sponsor-blinded, Randomized Study of AZD0901 Monotherapy Compared with Investigator’s Choice of Therapy in Second- or Later-Line Adult Participants with Advanced/Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoWe are doing this study to learn more about: the effectiveness and safety of the investigational study drug AZD0901 compared to a standard therapy that will be selected by your study doctor per your... -
NCT05953337
Radioembolization Oncology Trial Utilizing Transarterial Eye90 (ROUTE 90) for the Treatment of Hepatocellular Carcinoma (HCC)
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: AltamonteThe purpose of this study is to evaluate the safety and effectiveness of a new medical device and how well it works for people with HCC. The new medical device is called Eye90 microspheres (Eye90)... -
NCT06282575
An open-label randomized trial of the efficacy and safety of zanidatamab with standard-of-care therapy against standard-of-care therapy alone for advanced HER2-positive biliary tract cancer
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis is an open-label, randomized, multicenter, phase 3 study to investigate the efficacy and safety of zanidatamab plus CisGem with or without a PD-1/L1 inhibitor (physician’s choice of either... -
NCT05865535
AV-380-22-102: A Phase 1 Dose Escalation Study of AV-380 in Combination with Standard of Care Chemotherapy in Metastatic Cancer Patients with Cachexia and Elevated GDF-15 Levels
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe study involves research. The purpose of the study is to see if a single dose and multiple doses of the study drug, AV 380, are safe and tolerated in cancer participants. This study will also help... -
NCT05174169
NRG-GI008: COLON ADJUVANT CHEMOTHERAPY BASED ON EVALUATION OF RESIDUAL DISEASE (CIRCULATE-US)
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoctDNA-ve Cohort (Arms 1 + 2): Phase II: To compare time to ctDNA (+ve) status in ctDNA (-ve) cohort following resection of stage III colon cancer treated with immediate vs delayed (based on serial...