Cancer Research Clinical Trials
Search our team at AdventHealth Research Institute
Showing 1 - 12 of 108 clinical trials available
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NCT06459869
A multicentre, open label, non-randomized, phase 1b trial of NG-350A, a tumourselective anti-CD40-expressing adenoviral vector, in combination with chemoradiotherapy in locally advanced rectal cancer (FORTRESS)
This study is currently enrolling.Associated Conditions: GastrointestinalResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this research is to test an investigational drug called NG-350A as a possible treatment for locally advanced rectal cancer (LARC). An investigational drug is one that has not been... -
NCT05773144
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this research study is to determine if different durations of exercise can improve how well you tolerate chemotherapy for colon cancer. -
NCT05789433
Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer
This study is currently enrolling.Associated Conditions: Exercise & BioenergeticsResearch Area: Clinical Cancer ResearchResearch Location: OrlandoRESTORE-The purpose of this research study is to determine how different types of exercise change muscle tissue among people who have been diagnosed with colorectal cancer. -
NCT07028853
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MEVROMETOSTAT (PF-06821497) WITH ENZALUTAMIDE IN METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER
This study is currently enrolling.Associated Conditions: Urology of DenverResearch Area: Clinical Cancer ResearchResearch Location: Porter, Colorado -
NCT06966700
A Phase 3, Randomized, Open-label Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) Followed by carboplatin/Paclitaxel vs Chemotherapy, Both in Combination with Pembrolizumab as Neoadjuvant Therapy for Triple-Negative Breast Cancer (TNBC) or Hormone Receptor-low positive/HER2-negative Breast Cancer (TROFUSE-032)
This study is currently enrolling.Associated Conditions: BreastResearch Area: Clinical Cancer ResearchResearch Location: Orlando -
NCT06767514
A Randomized, Double-blinded, Multiregional Phase 3 Study of Ivonescimab Versus Pembrolizumab for the First-line Treatment of Metastatic Non-small Cell Lung Cancer in Patients Whose Tumors Demonstrate High PD-L1 Expression (TPS greater than or equal to 50%)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this research is to measure the safety and effectiveness of ivonescimab compared to pembrolizumab. Ivonescimab is an antibody designed to block proteins that help cancer cells grow and... -
NCT07223125
A Phase 1 Study of JNJ-89862175, an Antibody Drug Conjugate (ADC) Agent Targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 (ENPP3), for Advanced Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationA Phase 1 Study of JNJ-89862175, an Antibody Drug Conjugate (ADC) Agent Targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 (ENPP3), for Advanced Solid Tumors -
NCT06803680
A Phase 1, Open-Label Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-B455 in Patients With Selected Advanced or Metastatic Solid Tumors
This study is currently enrolling.Associated Conditions: MultitherapeuticResearch Area: Clinical Cancer ResearchResearch Location: CelebrationThe purpose of this study is to test if the study drug BGB-B455, when it is given on its own, is safe and tolerated in patients with solid tumors expressing the CLDN6 protein. -
NCT06452277
A Phase 3 open-label, randomized, active-controlled, multicenter trial to evaluate the efficacy and safety of orally administered BAY 2927088 compared with standard of care as a first-line therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with HER2-activating mutations (SOHO-02)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThe purpose of this study is to look at how well the new study drug works compared to standard medical care in participants with non-small cell lung cancer -
NCT06819007
A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer” GOG 3112/ DSI-T-DXd ENHERTU (DO-01); DESTINY-Ovarian01 (DO-01)] DS8201-772
This study is currently enrolling.Associated Conditions: GynecologyResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis study consists of two parts: Part 1 (safety run-in) and Part 2 (randomized part [like the flip of a coin]). The purpose of Part 1 is to learn more about the safety and tolerability of the... -
NCT06745323
A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects with Small Cell Lung Cancer (SCLC) (DeLLphi-309)
This study is currently enrolling.Associated Conditions: ThoracicResearch Area: Clinical Cancer ResearchResearch Location: OrlandoThis study is being done to learn more about tarlatamab in people with Small Cell Lung Cancer (SCLC; a type of fast-growing cancer that forms in tissues of the lung and can spread to other parts of... -
NCT06841354
A Phase 3, Randomized, Open-label Study Comparing Efficacy and Safety of Sacituzumab Tirumotecan (sac-TMT, MK-2870) as a Monotherapy and in Combination with Pembrolizumab (MK-3475) Versus Treatment of Physician’s Choice in Participants With Previously Untreated Locally Recurrent Unresectable or Metastatic Triple-Negative Breast Cancer Expressing PD L1 at CPS Less than 10 (TroFuse 11)
This study is currently enrolling.Associated Conditions: BreastResearch Area: Clinical Cancer ResearchResearch Location: AltamonteThis trial is testing sacituzumab tirumotecan (sac-TMT) when given alone and with pembrolizumab (pembro) in people with triple negative breast cancer (TNBC). The trial will test these drugs in people...